vital nutrients such as magnesium, vitamin B12, iron, calcium, and vitamin D. Use for more than a year reduces magnesium levels by up to 60%, which can trigger fatal ventricular arrhythmias. Vitamin B12 deficiency leads to cardiomyopathy and raises homocysteine levels by 40%, a toxic amino acid that directly damages coronary arteries. Even worse, PPIs negate the effect of clopidogrel (Plavix), a major blood thinning agent, leaving patients completely vulnerable to blood clots.
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Alternatives and weaning:
- Reduce the dose gradually (by 50%